Expression of Toll-Like Receptor Messenger Ribonucleic Acid in the Distal Facial Nerve After Facial Nerve Injury

نویسندگان

چکیده

Background and Objectives This study aimed to evaluate whether Toll-like receptors (TLRs) messenger ribonucleic acid (mRNA) were expressed in the facial nerve after incurring a crush or an injury of nerve.Materials Method An adult Sprague-Dawley underwent unilateral nerve. The was incurred by cutting at midpoint between trunk its branch. whisker movement vibrissae muscle examined 4 14 days injury. Real-time polymerase chain reaction performed for normal taken from left side damaged right side.Results On 4th day injury, expression TLR 9, 13 mRNA significantly lower injured groups than control group (<i>p</i><0.05). 14th 2 higher (<i>p</i><0.05).Conclusion expressions distal that group, but higher. Therefore, TLRs may be involved damage regeneration.

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ژورنال

عنوان ژورنال: Korean journal of otorhinolaryngology-head and neck surgery

سال: 2022

ISSN: ['2092-6529', '2092-5859']

DOI: https://doi.org/10.3342/kjorl-hns.2021.00129